SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Schedule 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c)
AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)
(Amendment No. 1)*
Alnylam Pharmaceuticals, Inc.
(Name of Issuer)
Common Stock
(Title of Class of Securities)
02043Q107
(CUSIP Number)
December 31, 2004
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[X] Rule 13d-1(d)
* The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following pages)
Page 1 of 18
Exhibit Index on Page 15
CUSIP NO. 02043Q107 13 G Page 2 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Polaris Venture Partners III, L.P. ("PVP III")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
2,313,914 shares, except that Polaris Venture Management Co.
III, L.L.C. ("Polaris III"), the general partner of PVP III,
may be deemed to have sole power to vote these shares, and
Jonathan A. Flint ("Flint"), Terrance G. McGuire ("McGuire"),
Stephen D. Arnold ("Arnold") and Alan G. Spoon ("Spoon"), the
managing members of Polaris III, may be deemed to have
NUMBER OF shared power to vote these shares.
SHARES -----------------------------------------------------------------
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY
EACH See response to row 5.
REPORTING -----------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
2,313,914 shares, except that Polaris III, the general
partner of PVP III, may be deemed to have sole power to
dispose of these shares, and Flint, McGuire, Arnold and
Spoon, the managing members of Polaris III, may be deemed to
have shared power to dispose of these shares.
-----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,313,914
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.1%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 3 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Polaris Venture Partners Entrepreneurs' Fund III, L.P.
("Entrepreneurs' III")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
60,124 shares, except that Polaris III, the general partner
of Entrepreneurs' III, may be deemed to have sole
power to vote these shares, and Flint, McGuire, Arnold and
Spoon, the managing members of Polaris III, may be deemed to
have shared power to vote these shares.
-----------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY See response to row 5.
OWNED BY -----------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON 60,124 shares, except that Polaris III, the general partner
WITH of Entrepreneurs' III, may be deemed to have sole power to
dispose of these shares, and Flint, McGuire, Arnold and
Spoon, the managing members of Polaris III, may be deemed to
have shared power to dispose of these shares.
-----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
60,124
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
0.3%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 4 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Polaris Venture Partners Founders' Fund III, L.P. ("Founders' III")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
36,492 shares, except that Polaris III, the general partner
of Founders' III, may be deemed to have sole power to vote
these shares, and Flint, McGuire, Arnold and Spoon, the
managing members of Polaris III, may be deemed to have shared
power to vote these shares.
NUMBER OF -----------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY See response to row 5.
EACH -----------------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 36,492 shares, except that Polaris III, the general partner
of Founders' III, may be deemed to have sole power to dispose
of these shares, and Flint, McGuire, Arnold and Spoon, the
managing members of Polaris III, may be deemed to have shared
power to dispose of these shares.
-----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
36,492
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
0.2%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
PN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 5 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Polaris Venture Management Co. III, L.L.C. ("Polaris III")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III, the
general partner of PVP III, Entrepreneurs' III and Founders'
III, may be deemed to have sole power to vote these shares,
and Flint, McGuire, Arnold and Spoon, the managing members of
Polaris III, may be deemed to have shared power to vote these
shares.
-----------------------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY See response to row 5.
OWNED BY -----------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON 2,410,530 shares, of which 2,313,914 are directly owned by
WITH PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III, the
general partner of PVP III, Entrepreneurs' III and Founders'
III, may be deemed to have sole power to vote these shares,
and Flint, McGuire, Arnold and Spoon, the managing members of
Polaris III, may be deemed to have shared power to dispose of
these shares.
-----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
See response to row 7.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,410,530
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.6%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
OO
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 6 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Jonathan A. Flint ("Flint")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
0 shares.
-----------------------------------------------------------------
6 SHARED VOTING POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
the general partner of PVP III, Entrepreneurs' III and
Founders' III. Flint is a managing member of Polaris III, and
SHARES may be deemed to have shared power to vote these shares.
BENEFICIALLY
OWNED BY -----------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON 0 shares.
WITH -----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
the general partner of PVP III, Entrepreneurs' III and
Founders' III. Flint is a managing member of Polaris III, and
may be deemed to have shared power to dispose of these
shares.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON
2,410,530
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.6%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 7 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Terrance G. McGuire ("McGuire")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
0 shares.
-----------------------------------------------------------------
6 SHARED VOTING POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
SHARES the general partner of PVP III, Entrepreneurs' III and
BENEFICIALLY Founders' III. McGuire is a managing member of Polaris III,
OWNED BY and may be deemed to have shared power to vote these shares.
EACH -----------------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 0 shares.
-----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
the general partner of PVP III, Entrepreneurs' III and
Founders' III. McGuire is a managing member of Polaris III,
and may be deemed to have shared power to dispose of these
shares.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON
2,410,530
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.6%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 8 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Stephen D. Arnold ("Arnold")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
0 shares.
-----------------------------------------------------------------
6 SHARED VOTING POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs'
III and 36,492 are directly owned by Founders' III. Polaris
NUMBER OF III is the general partner of PVP III, Entrepreneurs' III
SHARES and Founders' III. Arnold is a managing member of Polaris
BENEFICIALLY III, and may be deemed to have shared power to vote these
OWNED BY shares.
EACH -----------------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 0 shares.
-----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
the general partner of PVP III, Entrepreneurs' III and
Founders' III. Arnold is a managing member of Polaris III,
and may be deemed to have shared power to dispose of these
shares.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,410,530
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.6%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 9 of 18
--------------------------------------------------------------------------------
1 NAME OF REPORTING
SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Alan G. Spoon ("Spoon")
Tax ID Number:
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ]
(b) [X]
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S. Citizen
--------------------------------------------------------------------------------
5 SOLE VOTING POWER
0 shares.
-----------------------------------------------------------------
6 SHARED VOTING POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
NUMBER OF the general partner of PVP III, Entrepreneurs' III and
SHARES Founders' III. Spoon is a managing member of Polaris III,
BENEFICIALLY and may be deemed to have shared power to vote these shares.
OWNED BY -----------------------------------------------------------------
EACH 7 SOLE DISPOSITIVE POWER
REPORTING
PERSON 0 shares.
WITH -----------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,410,530 shares, of which 2,313,914 are directly owned by
PVP III, 60,124 are directly owned by Entrepreneurs' III and
36,492 are directly owned by Founders' III. Polaris III is
the general partner of PVP III, Entrepreneurs' III and
Founders' III. Spoon is a managing member of Polaris III,
and may be deemed to have shared power to dispose of these
shares.
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,410,530
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
[ ]
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
11.6%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON*
IN
--------------------------------------------------------------------------------
CUSIP NO. 02043Q107 13 G Page 10 of 18
ITEM 1(A). NAME OF ISSUER
Alnylam Pharmaceuticals, Inc.
ITEM 1(B). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES
300 Third Street
Cambridge, Massachusetts 02142
ITEM 2(A). NAME OF PERSONS FILING
This Statement is filed by Polaris Venture Partners III, L.P., a
Delaware limited partnership ("PVP III"), Polaris Venture Partners
Entrepreneurs' Fund III, L.P., a Delaware limited partnership
("Entrepreneurs' III"), Polaris Venture Partners Founders' Fund
III, L.P., a Delaware limited partnership ("Founders' III"),
Polaris Venture Management Co. III, L.L.C., a Delaware limited
liability company ("Polaris III"), Jonathan A. Flint ("Flint"),
Terrance G. McGuire ("McGuire"), Stephen D. Arnold ("Arnold") and
Alan G. Spoon ("Spoon"). Flint, McGuire, Arnold and Spoon are the
managing members of Polaris III. The foregoing entities and
individuals are collectively referred to as the "Reporting
Persons."
Polaris III, the general partner of PVP III, Entrepreneurs' III and
Founders' III, may be deemed to have sole power to vote and sole
power to dispose of shares of the issuer directly owned by PVP III,
Entrepreneurs' III and Founders' III. Flint, McGuire, Arnold and
Spoon are the managing members of Polaris III and may be deemed to
have shared power to vote and shared power to dispose of shares of
the issuer directly owned by PVP III, Entrepreneurs' III and
Founders' III.
ITEM 2(B). ADDRESS OF PRINCIPAL OFFICE
The address for each of the Reporting Persons is:
Polaris Venture Partners
1000 Winter Street, Suite 3350
Waltham, Massachusetts 02451
ITEM 2(C) CITIZENSHIP
PVP III, Entrepreneurs' III and Founders' III are Delaware limited
partnerships; Polaris III is a Delaware Limited Liability Company;
Flint, McGuire, Arnold and Spoon are United States citizens.
ITEM 2(D) AND (E). TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER
Common Stock
CUSIP # 02043Q107
ITEM 3. Not Applicable
ITEM 4. OWNERSHIP
The following information with respect to the ownership of the
Common Stock of the issuer by the persons filing this Statement is
provided as of December 31, 2004:
CUSIP NO. 02043Q107 13 G Page 11 of 18
(a) Amount beneficially owned:
See Row 9 of cover page for each Reporting Person.
(b) Percent of Class:
See Row 11 of cover page for each Reporting Person.
(c) Number of shares as to which such person has:
(i) Sole power to vote or to direct the vote:
See Row 5 of cover page for each Reporting
Person.
(ii) Shared power to vote or to direct the vote:
See Row 6 of cover page for each Reporting
Person.
(iii) Sole power to dispose or to direct the
disposition of:
See Row 7 of cover page for each Reporting
Person.
(iv) Shared power to dispose or to direct the
disposition of:
See Row 8 of cover page for each Reporting
Person.
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
Not applicable.
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.
Under certain circumstances set forth in the limited partnership
agreements of PVP III, Entrepreneurs' III and Founders' III, the
general and limited partners of each of such entities may be deemed
to have the right to receive dividends from, or the proceeds from,
the sale of shares of the issuer owned by each such entity of which
they are a partner.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP.
Not applicable.
CUSIP NO. 02043Q107 13 G Page 12 of 18
ITEM 10. CERTIFICATION.
Not applicable.
Page 13 of 18
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: February 14, 2005
POLARIS VENTURE PARTNERS III, L.P., /s/ Kevin Littlejohn
a Delaware Limited Partnership ----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
POLARIS VENTURE PARTNERS /s/ Kevin Littlejohn
ENTREPRENEURS' FUND III, L.P., ----------------------------------------
a Delaware Limited Partnership Signature
Kevin Littlejohn
Authorized Signatory
POLARIS VENTURE PARTNERS /s/ Kevin Littlejohn
FOUNDERS' FUND III, L.P., ----------------------------------------
a Delaware Limited Partnership Signature
Kevin Littlejohn
Authorized Signatory
POLARIS VENTURE
MANAGEMENT CO. III, L.L.C., /s/ Kevin Littlejohn
a Delaware Limited Liability Company ----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
JONATHAN A. FLINT /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
Page 14 of 18
TERRANCE G. MCGUIRE /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
STEPHEN D. ARNOLD /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
ALAN G. SPOON /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
Page 15 of 18
EXHIBIT INDEX
Found on
Sequentially
Exhibit Numbered Page
------- -------------
Exhibit A: Agreement of Joint Filing 16
Exhibit B: Reference to Kevin Littlejohn as Authorized Signatory 18
Page 16 of 18
EXHIBIT A
Agreement of Joint Filing
The undersigned hereby agree that a single Schedule 13G (or any
amendment thereto) relating to the Common Stock of Alnylam Pharmaceuticals, Inc.
shall be filed on behalf of each of the undersigned and that this Agreement
shall be filed as an exhibit to such Schedule 13G.
Dated: February 14, 2005
POLARIS VENTURE PARTNERS III, L.P., /s/ Kevin Littlejohn
a Delaware Limited Partnership ----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
POLARIS VENTURE PARTNERS /s/ Kevin Littlejohn
ENTREPRENEURS' FUND III, L.P., ----------------------------------------
a Delaware Limited Partnership Signature
Kevin Littlejohn
Authorized Signatory
POLARIS VENTURE PARTNERS /s/ Kevin Littlejohn
FOUNDERS' FUND III, L.P., ----------------------------------------
a Delaware Limited Partnership Signature
Kevin Littlejohn
Authorized Signatory
POLARIS VENTURE /s/ Kevin Littlejohn
MANAGEMENT CO. III, L.L.C., ----------------------------------------
a Delaware Limited Liability Company Signature
Kevin Littlejohn
Authorized Signatory
JONATHAN A. FLINT /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
Page 17 of 18
TERRANCE G. MCGUIRE /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
STEPHEN D. ARNOLD /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
ALAN G. SPOON /s/ Kevin Littlejohn
----------------------------------------
Signature
Kevin Littlejohn
Authorized Signatory
Page 18 of 18
EXHIBIT B
REFERENCE TO KEVIN LITTLEJOHN AS AUTHORIZED SIGNATORY
Kevin Littlejohn has signed the enclosed documents as Authorized Signatory. Note
that copies of the applicable Agreement to File Jointly and Statement Appointing
Designated Filer And Authorized Signatory are already on file with the
appropriate agencies.