UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC  20549


                                AMENDMENT NO.1 TO
                                    FORM 10-Q


                                   (MARK ONE)

           [X] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE

                         SECURITIES EXCHANGE ACT OF 1934


                  For the quarterly period ended: JUNE 30, 2001

                                       OR


          [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE

                         SECURITIES EXCHANGE ACT OF 1934


               For the transition period from _______ to ________

                        Commission File Number:  0-30235


                                 EXELIXIS, INC.
             (Exact name of registrant as specified in its charter)

                  Delaware                               04-3257395
      (State  or  other  jurisdiction  of            (I.R.S.  Employer
       incorporation  or  organization)             Identification  Number)

                                 170 Harbor Way
                                  P.O. Box 511
                          South San Francisco, CA 94083
          (Address of principal executive offices, including zip code)
                                  (650) 837-7000
              (Registrant's telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding  12  months  (or  for such shorter period that the registrant was
required  to  file  such  reports),  and  (2)  has  been  subject to such filing
requirements  for  the  past  90  days:

     Yes  [X]     No  [  ]


As  of  July  31,  2001, there were 49,161,649 shares of the registrant's common
stock  outstanding.




                                EXPLANATORY NOTE

Exelixis,  Inc.  is  filing this Amendment No. 1 to Form 10-Q as an exhibit-only
filing.  Exelixis  is refiling Exhibit 10.28, Collaboration Agreement, dated May
22,  2001,  by  and  between  Exelixis,  Inc. and Protein Design Labs, Inc., and
confidential  treatment has been requested for certain portions of such exhibit.




                                    SIGNATURE



Pursuant  to  the  requirements  of  the  Securities  Exchange  Act of 1934, the
registrant  has  duly caused this amendment to report to be signed on its behalf
by  the  undersigned,  thereunto  duly  authorized.


Date:  September  17,  2001





                              EXELIXIS,  INC.



                              /s/  Glen  Y.  Sato
                              -------------------
                              Glen  Y.  Sato
                              Chief  Financial  Officer, Vice  President  of
                              Legal  Affairs  and  Secretary
                              (Principal  Financial  and  Accounting  Officer)



                                INDEX TO EXHIBITS

Exhibit
Number     Description  of  Document
------     -------------------------


2.1        Share  Exchange  and  Assignment Agreement, dated April 23, 2001,
           by and among  Exelixis,  Inc.  and  the  Artemis  stockholders
           named therein.  (1)
3.1        Amended  and  Restated  Certificate  of  Incorporation  (2)
3.2        Amended  and  Restated  Bylaws  (2)
4.1        Specimen  Common  Stock  Certificate  (2)
4.2*       Form  of  Convertible  Promissory  Note,  dated  May 22, by and
           between Exelixis,  Inc.  and  Protein  Design  Labs,  Inc.
4.3*       Form of Note Purchase Agreement, dated May 22, by and between
           Exelixis, Inc.  and  Protein  Design  Labs,  Inc.
10.28**    Collaboration  Agreement,  dated  May  22,  2001,  by  and  between
           Exelixis,  Inc.  and  Protein  Design  Labs,  Inc.
--------------------------------------------------------------------------------
(1)     Filed  with Exelixis' Item 2 Current Report on Form 8-K filed on May 15,
        2001  and  incorporated  herein  by  reference.
(2)     Filed with Exelixis' Registration Statement on Form S-1, as amended (No.
        333-96335),  declared  effective  by  the  Securities and Exchange
        Commission on April  10,  2000,  and  incorporated  herein  by
        reference.
*       Previously  filed.
**      Filed herewith, and confidential treatment requested for certain
        portions of this exhibit.