Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MEANWELL CLIVE
   2. Issuer Name and Ticker or Trading Symbol
ENDO PHARMACEUTICALS HOLDINGS INC [ENDP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
8 CAMPUS DRIVE		 3. Date of Earliest Transaction (Month/Day/Year)
03/12/2010
(Street)

PARSIPPANY, NJ 07054		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, par value $.01 per share 03/12/2010   M   2,009 A $ 0 (1) 11,855 (2) D  
Common Stock, par value $.01 per share 03/12/2010   M   1,371 A $ 0 (3) 11,855 (2) D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
2007 Stock Incentive Plan Restricted Stock Units (RSU) (4) 03/12/2010   M     2,009 03/12/2010 03/12/2010(5) Common Stock 2,009 $ 0 2,009 D  
2007 Stock Incentive Plan Restricted Stock Units (RSU) (4) 03/12/2010   M     1,371 03/12/2010 03/12/2010(6) Common Stock 1,371 $ 0 0 D  
2007 Stock Incentive Plan Restricted Stock Units (RSU) (4) 03/12/2010   A   2,834     (7) 03/12/2012(7) Common Stock 2,834 (8) 2,834 D  
2007 Stock Incentive Plan Stock Options (9) $ 23.82 03/12/2010   A   8,094     (10) 03/12/2020 Common Stock 8,094 (8) 8,094 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MEANWELL CLIVE
8 CAMPUS DRIVE
PARSIPPANY, NJ 07054		   X      

Signatures

 /s/ Caroline B. Manogue, by Power of Attorney   03/16/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This represents vesting of restricted stock units granted to Dr. Meanwell on March 12, 2009. Upon each vesting date, each vested restricted stock unit automatically converts into one (1) share of common stock of Endo Pharmaceuticals Holdings Inc.
(2) This number represents (i) 2,262 shares of restricted stock, all of which are fully vested and (ii) 9,593 restricted stock units (including the 2,834 restricted stock units reported in Table II), 4,750 of which are fully vested. Dr. Meanwell's beneficial ownership disclosed in this table excludes all shares held by Dr. Meanwell indirectly, including shares underlying stock options.
(3) This represents vesting of restricted stock units granted to Dr. Meanwell on March 12, 2008. Upon each vesting date, each vested restricted stock unit automatically converts into one (1) share of common stock of Endo Pharmaceuticals Holdings Inc.
(4) Upon each vesting date, each vested restricted stock unit automatically converts into one (1) share of Endo common stock.
(5) Fifty percent (50%) of Dr. Meanwell's March 12, 2009 grant of restricted stock units (RSUs) generally vest on each of March 12, 2010 and March 12, 2011. The 2,009 shown here is the amount that vested on March 12, 2010. Upon vesting, we consider the underlying RSUs to be expired.
(6) Fifty percent (50%) of Dr. Meanwell's March 12, 2008 grant of restricted stock units (RSUs) generally vest on each of March 12, 2009 and March 12, 2010. The 1,371 shown here is the amount that vested on March 12, 2010. Upon vesting, we consider the underlying RSUs to be expired.
(7) These restricted stock units (RSUs) generally vest 50% per year on each of March 12, 2011 and March 12, 2012. Upon vesting, we consider the underlying RSUs to be expired.
(8) These securities were granted to Dr. Meanwell in consideration of his services on the Endo Pharmaceuticals Holdings Inc. Board of Directors.
(9) Representing the right to buy shares of common stock, par value $0.01 per share, of Endo Pharmaceuticals Holdings Inc.
(10) These stock options are generally exercisable 25% per year on each of March 12, 2011, March 12, 2012, March 12, 2013 and March 12, 2014.

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