UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 10-QSB
(Mark One)
 x
QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
 
For the quarterly period ended January 31, 2008

o
TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE EXCHANGE ACT
 
For the transition period from to ________________ to ________________
 
Commission file number   000 28489
  
ADVAXIS, INC.
(Exact name of small business issuer as specified in its charter)
     
   
Delaware
 
841521955
(State or other jurisdiction of incorporation or organization)
 
(IRS Employer Identification No.)
   

The Technology Centre of New Jersey, 675 Route 1, Suite 119, North Brunswick, NJ 08902
(Address of principal executive offices)
 
 
(732) 545-1590
(Issuer’s telephone number)
 

  
(Former name, former address and former fiscal year, if changed since last report)
 
 
Check whether the issuer (1) filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x  No o
 
State the number of shares outstanding of each of the issuer’s classes of common equity, as of March 7, 2008

108,169,830 shares outstanding of the Company’s Common Stock, par value $.001 per share
 
Transitional Small Business Disclosure Format (Check one): Yes o   No x
 
Persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.


Table of Contents
 
ADVAXIS, INC.
(A Development Stage Company)
January 31, 2008

INDEX
 
 
Page No.
 
 
 
 
 
 
 
 
2
 
 
3
 
 
4
 
 
6
 
 
8
 
 
11
 
 
 
 
 
11
 
 
11
 
 
12
 
- 1 -
 
Table of Contents
 
PART I-FINANCIAL INFORMATION
Item 1. Financial Statements
ADVAXIS, INC.
(A Development Stage Company)
Balance Sheet
(Unaudited)
 
 
  
January 31, 2008
  
ASSETS
      
Current Assets:
      
Cash
  
$
2,826,873
  
Prepaid expenses
    
147,873
  
  Total Current Assets
    
2,974,746
  
 
        
Property and Equipment (net of accumulated depreciation of $64,747)
    
114,617
  
Intangible Assets (net of accumulated amortization of $164,990)
    
1,125,111
  
Other Assets
    
3,876
  
  Total Assets
  
$
4,218,350
  
LIABILITIES & SHAREHOLDERS’ EQUITY
        
Current Liabilities:
        
Accounts payable
  
$
801,340
  
Accrued expenses
    
426,664
  
Deferred revenue
    
52,597
  
Interest payable
    
14,568
  
Notes payable - current portion
    
66,850
  
Total Current Liabilities
    
1,362,019
  
 
        
Notes payable - net of current portion
    
16,098
  
Total Liabilities
  
$
1,378,117
  
 
        
Shareholders’ Equity:
        
Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued and oustanding     -  
Common Stock - $0.001 par value; authorized 500,000,000 shares, issued and outstanding 107,957,977
    
107,957
  
Additional Paid-In Capital
    
16,250,525
  
Deficit accumulated during the development stage
    
(13,518,249
)
Total Shareholders' Equity
  
$
2,840,233
  
  Total Liabilities & Shareholders’ Equity
  
$
4,218,350
  
 
  The accompanying footnotes are an integral part of these financial statements.

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ADVAXIS, INC.
(A Development Stage Company)
Statement of Operations
(Unaudited)
 
 
  
3 Months
Ended
January 31,
  
3 Months
Ended
January 31,
  
Period from
March 1, 2002 (Inception) to
January 31,
  
 
  
2008
  
2007
  
2008
  
Revenue
  
$
22,403
  
$
146,307
  
$
1,281,839
  
 
                  
Research & Development Expenses
    
682,163
    
494,107
    
6,058,307
  
General & Administrative Expenses
    
772,590
    
845,072
    
7,745,477
  
Total Operating expenses
    
1,454,752
    
1,339,179
    
13,803,784
  
 
                  
Loss from Operations
    
(1,432,350
)
  
(1,192,872
)
  
(12,521,944
)
 
                  
Other Income (expense):
                    
Interest expense
    
(1,987
)
  
(153,355
)
  
(1,075,207
)
Other Income
    
32,714
    
26,326
    
232,542
  
Gain on note retirement
    
-
    
-
    
1,532,477
  
Net changes in fair value of common stock warrant liability and embedded derivative liability
    
-
    
1,282,871
    
(1,642,232
)
Net loss
    
(1,401,623
)
  
(37,030
)
  
(13,474,365
)
 
                  
Dividends attributable to preferred shares
    
-
    
-
    
43,884
  
 
                  
Net loss applicable to Common Stock
    
(1,401,623
)
$
(37,030
)
$
(13,518,249
)
 
                
Net loss per share, basic and diluted
  
$
(0.01
)
$
(0.00
)
    
 
                
Weighted average number of shares outstanding basic and diluted
    
107,957,977
    
41,168,537
      
 
The accompanying footnotes are an integral part of these financial statements.

 
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Table of Contents
 
ADVAXIS, INC.
(A Development Stage Company)
Statement of Cash Flows
(Unaudited)
 
 
  
  3 Months ended
January 31,
  
  3 Months ended
January 31,
  
  Period from
March 1, 2002 (Inception) to
January 31,
  
 
  
  2008
  
  2007
  
  2008
  
OPERATING ACTIVITIES
              
Net loss
  
$
(1,401,623
)
$
(37,030
)
$
(13,474,365
)
Adjustments to reconcile net loss to net cash used in operating activities:
                  
Non-cash charges to consultants and employees for options and stock
    
51,889
    
392,439
    
1,549,755
  
Amortization of deferred financing costs
    
-
    
29,606
    
260,000
  
Non-cash interest expense
   
1,007
    
82,399
    
511,285
  
Loss (Gain) on change in value of warrants and embedded derivative
    
-
    
(1,282,871
)
  
1,642,232
  
Value of penalty shares issued
    
-
    
-
    
117,498
  
Depreciation expense
    
8,794
    
6,334
    
64,747
  
Amortization expense of intangibles
    
15,858
    
13,241
    
168,161
  
Gain on note retirement
    
-
    
-
    
(1,532,477
)
Decrease (Increase) in prepaid expenses
    
52,044
    
21,382
    
(147,873
)
Decrease (Increase) in other assets
    
-
    
724
    
(3,876
)
Increase in accounts payable
    
14,043
    
3,447
    
1,238,546
  
Increase in accrued expenses
    
121,641
    
6,047
    
410,475
  
Increase in interest payable
    
-
    
40,518
    
18,291
  
Increase (Decrease) in deferred revenue
    
52,597
    
(12,456
)
  
52,597
  
Net cash used in operating activities
    
(1,088,750
)
  
(736,220
)
  
(9,125,003
)
INVESTING ACTIVITIES
                  
Cash paid on acquisition of Great Expectations
    
-
    
-
    
(44,940
)
Purchase of property and equipment
    
(6,969
)
  
(29,400
)
  
(133,784
)
Cost of intangible assets
    
(42,834
)
  
(16,674
)
  
(1,368,223
)
Net cash used in Investing Activities
    
(49,803
)
  
(46,074
)
  
(1,546,947
)
FINANCING ACTIVITIES
                    
Proceeds from convertible secured debenture
                
960,000
  
Cash paid for deferred financing costs
          
-
    
(260,000
)
Principal Payments on notes payable
    
(3,546
)
  
(1,063
)
  
(95,633
)
Proceeds from notes payable
          
-
    
1,271,224
)
Net proceeds of issuance of Preferred Stock
          
-
    
235,000
  
Payment on cancellation of Warrants
                
(600,000
)
Proceeds of issuance of Common Stock, net of issuance costs
    
(78,012
)
  
-
    
11,988,232
  
Net cash (used in) provided by Financing Activities
    
(81,558
)
  
(1,063
)
  
13,498,823
  
Net (Decrease) increase in cash
    
(1,215,111
)
  
(783,357
)
  
2,826,873
  
Cash at beginning of period
    
4,041,984
    
2,761,166
    
-
  
Cash at end of period
  
$
2,826,873
  
$
1,977,809
  
$
2,826,873
  
 
The accompanying footnotes are an integral part of these financial statements.

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Table of Contents
 
Supplemental Schedule of Noncash Investing and Financing Activities
 
 
  
3 Months ended
January 31,
  
3 Months ended
January 31,
  
  Period from
March 1, 2002
(Inception) to
January 31,
  
   
  2008
  
  2007
  
  2008
  
Equipment acquired under capital lease
  
$
—
  
$
45,580
  
$
45,580
  
Common Stock issued to Founders
    
—
    
—
  
$
40
  
Notes payable and accrued interest converted to Preferred Stock
    
—
    
—
  
$
15,969
  
Stock dividend on Preferred Stock
    
—
    
—
  
$
43,884
  
Notes payable and accrued interest converted to Common Stock
        
$
$150,000
  
$
2,513,158
  
Intangible assets acquired with notes payable
    
—
    
—
  
$
360,000
  
Debt discount in connection with recording the original value of the embedded derivative liability
    
—
    
—
    
512,865
  
Allocation of the original secured convertible debentures to warrants
    
—
    
—
  
$
214,950
  
Warrants Issued in connection with issuance of common stock
    
—
    
—
    
1,505,550
  
 
 The accompanying footnotes are an integral part of these financial statements.
 
- 5 -
 
Table of Contents
 
 ADVAXIS, INC.
NOTES TO THE FINANCIAL STATEMENTS

1.
Business description
 
We are a development stage biotechnology company utilizing multiple mechanisms of immunity with the intent to develop cancer vaccines that are more effective and safer than existing vaccines. To that end, we have licensed rights from the University of Pennsylvania (“Penn”) to use a patented system to engineer a live attenuated Listeria monocytogenes bacteria (the “Listeria System”) to secrete a protein sequence containing a tumor-specific antigen. Using the Listeria System, we believe we will force the body’s immune system to process and recognize the antigen as if it were foreign, creating the immune response needed to attack the cancer. Our licensed Listeria System, developed at Penn over the past 10 years, provides a scientific basis for believing that this therapeutic approach induces a significant immune response to a tumor. Accordingly, we believe that the Listeria System is a broadly enabling platform technology that can be applied to many types of cancers. In addition, we believe there may be useful applications in infectious diseases and auto-immune disorders. The therapeutic approach that comprises the Listeria System is based upon the innovative work of Yvonne Paterson, Ph.D., Professor of Microbiology at Penn, involving the creation of genetically engineered Listeria that stimulate the innate immune system and induce an antigen-specific immune response involving humoral and cellular components. On July 1, 2002 (effective date) we entered into an exclusive 20-year license from Penn to exploit the Listeria System, subject to meeting various royalty and other obligations (the “Penn License”) which was amended and restated on February 13, 2007. The First Amendment to the Amended and Restated Patent License Agreement was entered into on March 26, 2007 to exercise its option to license an additional Listeria-Based and LLO-Based Vaccine patent/docket and have agreed to license 12 other patents/dockets.
 
We have focused our initial development efforts on five lead compounds. In February 2006 we commenced a Phase I/II clinical study of Lovaxin C, a vaccine with a potential for treatment of cervical cancer. We completed this clinical study in the fourth fiscal quarter 2007 after dosing 15 patients with end-stage cervical cancer conducted in Mexico, Serbia and Israel and met our trial objective. The objective of this trial was to establish a range of safe doses up to a maximally tolerated dose, which was achieved.
 
Based upon the outcome of our phase I/II trial in advanced cervical cancer, we plan on undertaking a phase II trial in stage 2/3 Cervical Intraepithelial Neoplasia (CIN). Stage 3 CIN is carcinoma in situ, and is a non-invasive form of cervical cancer. Stages 1 and 2 CIN are commonly called cervical dysplasia. Thus CIN is the name of the disease that can increase in severity to become invasive cervical cancer. While CIN frequently regresses spontaneously, over 250,000 surgical procedures are performed in the US annually to prevent progression from CIN to invasive cancer. We intend to begin this trial in the fourth fiscal quarter of 2008.

The accompanying unaudited interim consolidated financial statements include all adjustments (consisting only of those of a normal recurring nature) necessary for a fair statement of the results of the interim period. These interim Financial Statements should be read in conjunction with the Company’s Financial Statements and Notes for the year ended October 31, 2007 filed on Form 10-KSB. We believe these financial statements reflect all adjustments (consisting only of normal, recurring adjustments) that are necessary for a fair presentation of our financial position and results of operations for the periods presented. Results of operations for the interim periods presented are not necessarily indicative of results to be expected for the year.
 
The preparation of financial statements in conformity with U.S. Generally Accepted Accounting Principles requires management to make estimates and assumptions that affect the reported amounts and the disclosure of contingent amounts in the financial statements and accompanying notes. Actual results could differ from those estimates.

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. The Company has suffered losses that raise substantial doubt about its ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.
 
Since our inception until January 31, 2008, the Company has reported accumulated net losses of $13,518,249 and recurring negative cash flows from operations. In order to maintain sufficient cash and investments to fund future operations, we are seeking to raise additional capital in fiscal year 2008 through various financing alternatives. If additional capital were raised through the sale of equity or convertible debt securities, the issuance of such securities would result in additional dilution to our existing stockholders. We believe that the offering proceeds for the October 17, 2007 raise will be sufficient to sustain our plan of operations for the next six months. However, the company cannot provide assurances that our plans will not change, or that changed circumstances will not result in the depletion of capital resources more rapidly than anticipated. If we are unable to obtain additional sources of financing or generate sufficient cash flows from sufficient capital, it could create a material adverse effect on future operating prospects of the Company.

Since inception through January 31, 2008, all of the Company’s revenue has been from grants. For the three month period ended January 31, 2008, all of the revenue was received from the New Jersey Commission on Science and Technology.
 
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Table of Contents

 
Intangible Assets:
 
Intangible assets primarily consist of legal and filing costs associated with obtaining trademarks, patents and licenses. The license and patent costs capitalized primarily represent the value assigned to the Company’s 20-year exclusive worldwide license agreement with Penn which are amortized on a straight-line basis over their remaining useful lives which are estimated to be twenty years from the effective date of Penn Agreement dated July 1, 2002. The value of the license and patents are based on management’s assessment regarding the ultimate recoverability of the amounts paid and the potential for alternative future uses. This license includes the exclusive right to exploit 12 issued patents and the rights to exploit the majority of the 46 pending patents subject to finalization of the Second Amendment to the Amended and Restated Agreement. The Company exercised its option under the Second Amended and Restated Patent License Agreement to license a majority of these pending patents for a fee of $311,000 but has not finalized this Agreement. As of the date of this filing we are negotiating in a period of good faith on the form of payment. As of January 31, 2008, all gross capitalized costs associated with the licenses and patents filed and granted as well as and costs associated with patents pending are $1,199,387 (excluding the Second Amendment) as shown under license and patents on the table below. Out of the $1,199,387 capitalized cost the cost of the patents and licenses issued is estimated to be $458,983 and cost of the patents pending or in process of filing is estimated to be $740,404. The expirations of the existing patents range from 2014 to 2020. Capitalized costs associated with patent applications that are abandoned without future value are charged to expense when the determination is made not to pursue the application. No patent applications without value were abandoned and charged to expense in the current or prior year. Amortization expense for licensed technology and capitalized patent cost is included in general and administrative expense.
 
Under the amended and restated agreement we are billed actual patent expenses as they are passed through from Penn. The following is a summary of the intangibles assets as of the following fiscal periods:

 
  
October 31, 2007
  
  January 31, 2008
  
Increase/Decrease
  
Trademark
  
$
87,857
  
$
90,714
  
$
2,857
  
License
    
496,127
    
529,915
    
33,788
  
Patents
    
663,283
    
669,472
    
6,189
  
Total intangibles
    
1,247,267
    
1,292,101
    
42,834
  
Accumulated Amortization
    
(149,132
)
  
(164,990
)
  
(15,858
)
Intangible Assets
  
$
1,098,135
  
$
1,125,111
  
$
26,976
  

The Company reviews long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. An asset is considered to be impaired when the sum of the undiscounted future net cash flows expected to result from the use of the asset and its eventual disposition exceeds its carrying amount. The amount of impairment loss, if any, is measured as the difference between the net book value of the asset and its estimated fair value.

 
Loss Per Share:

Basic loss per share is computed by dividing net loss by the weighted-average number of shares of common stock outstanding during the periods. Diluted earnings per share gives effect to dilutive options, warrants, convertible debt and other potential common stock outstanding during the period. Therefore, the impact of the potential common stock resulting from warrants, outstanding stock options and convertible debt are not included in the computation of diluted loss per share, as the effect would be anti-dilutive. The table sets forth the number of potential shares of common stock that have been excluded from diluted net loss per share
 
   
As of
January 31, 2007
  
As of
January 31, 2008
  
Warrants
    
25,009,220
    
87,713,770
  
Stock Options
    
8,126,123
    
8,512,841
  
Convertible Debt (1)
    
17,317,487
        
Total All
    
50,452,830
    
96,226,611
  
 
(1) Conversion of the outstanding principal of $2,550,000 converted at 95% of the January 31, 2007 closing price of $0.155 per share or $0.147 per share.
 
 
Uncertain Tax Provisions:
 
Effective November 1, 2007 the Company adopted FASB Interpretation No. 48 “Accounting for Uncertainty in Income Taxes (an interpretation of FASB Statement No. 109)” (“FIN 48”). FIN 48 clarifies the accounting for uncertainty in tax positions and requires that companies recognize in their financial statements the impact of a tax position, if that position is more likely than not of being sustained on audit, based on the technical merits of the position. The adoption of FIN 48 in the first quarter of fiscal 2008 did not have an impact on the Company’s financial condition or results of operations.

- 7 -
 
Table of Contents

 
Secured Convertible Debenture:

Pursuant to a Securities Purchase Agreement dated February 2, 2006 ($1,500,000 principal amount) and March 8, 2006 ($1,500,000 principal amount) we issued to Cornell Capital Partners, LP (“Cornell”) $3,000,000 principal amount of the Company’s Secured Convertible Debentures due February 1, 2009 (the “Debentures”) at face amount, and five year Warrants to purchase 4,200,000 shares of Common Stock at the price of $0.287 per share and five year B Warrants to purchase 300,000 shares of Common Stock at a price of $0.3444 per share.
 
The Company measured the fair value of the warrants and embedded conversion features at each reporting date using the Black-Scholes-Merton valuation model based on the current assumptions at that point in time. This calculation has resulted in a fair market value significantly different than the previous reporting period. The increase or decrease in the fair market value of the warrants and embedded conversion feature at each period results in a non-cash income or expense which is recorded in other income (expense) in the Statement of Operations along with corresponding changes in fair value of the liability.
 
The Company measured the fair value of the warrants on the date of each reporting period until the debt was extinguished on October 17, 2007. Changes that occurred in the January 31, 2007 reporting period resulted in a decrease in the fair value of the warrants of and embedded derivative of $1,282,871 recorded in the Statement of Operations as income to Net Change in Fair Value of Common Stock Warrant and Embedded Derivative Liability.

Item 2. Management’s Discussion and Analysis
 
The Company has included in this Quarterly Report certain “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 concerning the Company’s business, operations and financial condition. “Forward-looking statements” consist of all non-historical information, and the analysis of historical information, including the references in this Quarterly Report to future revenues, collaborative agreements, future expense growth, future credit exposure, earnings before interest, taxes, depreciation and amortization, future profitability, anticipated cash resources, anticipated capital expenditures, capital requirements, and the Company’s plans for future periods. In addition, the words “could”, “expects”, “anticipates”, “objective”, “plan”, “may affect”, “may depend”, “believes”, “estimates”, “projects” and similar words and phrases are also intended to identify such forward-looking statements.
 
Actual results could differ materially from those projected in the Company’s forward-looking statements due to numerous known and unknown risks and uncertainties, including, among other things, unanticipated technological difficulties, the length, scope and outcome of our clinical trial, costs related to intellectual property, cost of manufacturing and higher consulting costs, product demand, changes in domestic and foreign economic, market and regulatory conditions, the inherent uncertainty of financial estimates and projections, the uncertainties involved in certain legal proceedings, instabilities arising from terrorist actions and responses thereto, and other considerations described as “Risk Factors” in other filings by the Company with the SEC. Such factors may also cause substantial volatility in the market price of the Company’s Common Stock. All such forward-looking statements are current only as of the date on which such statements were made. The Company does not undertake any obligation to publicly update any forward-looking statement to reflect events or circumstances after the date on which any
such statement is made or to reflect the occurrence of unanticipated events.

Plan of Operations

We were originally incorporated in the state of Colorado on June 5, 1987 under the name Great Expectations, Inc. We were administratively dissolved on January 1, 1997 and reinstated June 18, 1998 under the name Great Expectations and Associates, Inc. In 1999, we became a reporting company under the Securities Exchange Act of 1934 (the “Exchange Act’). Until November 2004, we were a publicly-traded “shell” company without any business until November 12, 2004 when we acquired Advaxis, Inc., a Delaware corporation (“Advaxis”), through a Share Exchange and Reorganization Agreement, dated as of August 25, 2004 (the “Share Exchange”), by and among Advaxis, the stockholders of Advaxis and us. As a result of such acquisition, Advaxis became our wholly-owned subsidiary and our sole operating company. On December 23, 2004, we amended and restated our articles of incorporation and changed our name to Advaxis, Inc. On June 6, 2006 our shareholders approved the reincorporation of the Company from the state of Colorado to the state of Delaware by merging the Company into its wholly-owned subsidiary, which was effected on June 20, 2006. As used herein, the words “Company” and "Advaxis" refer to the current Delaware Corporation only unless the context references such entity prior to the June 20, 2006 reincorporation into Delaware. Our principal executive offices are located at Technology Centre of NJ, 675 US Highway One, North Brunswick, NJ 08902 and our telephone number is (732) 545-1590.
 
On July 28, 2005 we began trading on the Over-The-Counter Bulletin Board (OTC:BB) under the ticker symbol ADXS.
 
We are a biotechnology company utilizing multiple mechanisms of immunity with the intent to develop cancer vaccines that are more effective and safer than existing vaccines. We believe that by using our licensed Listeria System to engineer a live attenuated Listeria monocytogenes bacteria to secrete a protein sequence containing a tumor-specific antigen, we will force the body’s immune system to process and recognize
 
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Table of Contents

the antigen as if it were foreign, creating the immune response needed to attack the cancer. The licensed Listeria System, developed at Penn over the past 10 years, provides a scientific basis for believing that this therapeutic approach induces a significant immune response to the tumor. Accordingly, we believe that the Listeria System is a broadly enabling platform technology that can be applied in many cancers, infectious diseases and auto-immune disorders.
 
We have no customers. We are in the development stage and have focused our initial development efforts on five lead compounds. In February 2006 we received governmental approvals in Mexico, Israel and Serbia to commence in those countries a Phase I clinical study of Lovaxin C, a vaccine with a potential for treatment of cervical and neck cancer. We completed this clinical study in the fourth fiscal quarter 2007. The study included 15 patients with advanced cervical cancer and met our trial objectives.
 
Three months ended January 31, 2008 Compared to the three months ended January 31, 2007
 
Revenue. Our revenue decreased by $123,904, or 85%, to $22,403 for the three months ended January 31, 2008 (“Fiscal 2008 Quarter”) as compared with $146,307 for the three months ended January 31, 2007 (“Fiscal 2007 Quarter”) primarily due to the $133,850 of grant money received from the National Cancer Institute in the fiscal 2007 Quarter as compared to the grant from the State of New Jersey received in the Fiscal 2008 Quarter.
 
Research and Development Expenses. Research and development expenses increased by $188,055, or 38%, to $682,162 for the Fiscal 2008 Quarter as compared with $494,107 for the Fiscal 2007 Quarter, principally attributable to the following:
 
·
Clinical trial expenses decreased by $63,281, or 49%, to $66,621 from $129,902 due to our higher clinical trial activity in the Fiscal 2007 Quarter compared to the close out phase in the Fiscal 2008 Quarter.
·
Wages, options and lab costs increased by $28,720, or 11% to $283,858 from $255,138 principally due to our expanded research & development efforts and a wage increase on November 1, 2007.
·
Consulting expenses increased by $23,799, or 152%, to $39,411 from $15,612, primarily reflecting the higher effort required to prepare the Investigational New Drug filing for the FDA in the Fiscal 2008 Quarter compared to the same period last year.
·
Subcontracted research expenses decreased by $50,644, or 55%, to $41,225 from $91,869, primarily reflecting the reduced subcontract work performed by Dr. Paterson at Penn, pursuant to the NCI grants in the first quarter Fiscal 2008 Quarter compared to the same period last year.
·
Manufacturing expenses increased by $222,822, to $224,407 from $1,585; the result of the ongoing clinical supply program for our upcoming Phase II trial compared to no manufacturing program in the Fiscal 2007 Quarter.
·
Toxicology study expenses of $26,640, incurred in the Fiscal 2008 Quarter, are a result of an ongoing toxicology study by Pharm Olam in connection with our Lovaxin C product candidates in anticipation of clinical studies in 2008, no such expenses were incurred in the Fiscal 2007 Quarter.
 
We anticipate a continued increase in R&D expenses as a result of expanded development and commercialization efforts related to toxicology studies, clinical trials, and product development, and expenses to be incurred in the development of strategic and other relationships required ultimately if the licensing, manufacture and distribution of our product candidates are undertaken.

General and Administrative Expenses. General and administrative expenses decreased by $72,482, or 9%, to $772,590 for the Fiscal 2008 Quarter as compared with $845,072 for the Fiscal 2007 Quarter, primarily attributable to the following:

·
Wages, Options and benefit expenses increased by $138,158, or 84% to $301,814 from $163,656 due to the effect of hiring the Chief Executive Officer (“CEO”) midway through the Fiscal 2007 Quarter compared to his employment for the full Fiscal 2008 Quarter. He also received an annual pay increase of $100,000 due to a successful milestone on October 17, 2007. Additionally there were other wage increases on November 1, 2007. An increase of option expense of $32,876 to $52,650, or 166% from $19,774 is primarily due to the CEO’s options granted as part of his employment agreement. In Fiscal 2008 Quarter the expense included three months of vesting versus one month in the Fiscal 2007 Quarter.
·
Consulting fees and expenses decreased by $358,029, or 74%, to $125,646 from $483,675. This decrease was primarily attributed to: (i) a decrease of $159,909 in option expense recorded in the Fiscal 2007 Quarter primarily due to an amendment of Mr. Appel’s (LVEP) consulting agreement compared to no options recorded in the Fiscal Quarter 2008; (ii) a decrease of $204,852 primarily due to the issuance to Mr. Appel of 1,000,000 shares of common stock of the Company ($200,000) and (iii) a $41,667 decrease of Mr. Appel’s bonus recorded in the Fiscal 2007 Quarter and none recorded in the Fiscal 2008 Quarter. These decreases in expenses were partially offset by the increase in other consulting expenses due to financial advisor fees of $48,399 recorded in the Fiscal 2008 Quarter verses the fees for other consultants in the Fiscal 2007 Quarter.
·
Penalty expense increased by $31,778 to $31,778. This expense was recorded in the Fiscal 2008 Quarter due to the delay of effectiveness of the registration statement on Form SB-2, File No. 333-147752.
·
An increase in legal, accounting, professional and public relations expenses of $76,238, or 66%, to $191,205 from $114,967, primarily as a result of growth in the Company and additional cost of being a public company.
 
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·
Amortization of intangibles and depreciation of fixed assets increased by $5,077, or 26%, to $24,652 from $19,575 primarily due to an increase in fixed assets and intangibles in the Fiscal 2008 Quarter compared to the Fiscal 2007 Quarter.
·
Overall occupancy and conference related expenses increased by $34,296 or 54% to $97,495 from $63,199. Overall conference expense has increased by $30,960 in the Fiscal 2008 Quarter due to the participation in several cancer conferences. Additional expenses for publication material were partially offset by lower director and officer’s insurance costs amounting to $8,728 for the Fiscal 2008 Quarter.
 
Other Income (expense). Other Income (expense) decreased by $1,125,115 to $30,728 for Fiscal 2008 Quarter from income of $1,155,842 for the Fiscal 2007 Quarter. During the Fiscal 2007 and the Fiscal 2008 Quarters, we recorded interest expense of ($153,355) and ($1,987) respectively, primarily related to interest accrued on our outstanding secured convertible debenture issued on February 2 and March 8, 2006. Interest earned on investments for the Fiscal 2007 and Fiscal 2008 Quarters amounted to $26,326 and $32,714, respectively. In the Fiscal 2007 Quarter there was a net change of $1,282,871 in the fair value of common stock warrants and embedded derivative liabilities recorded as income (non-cash item) compared to the fair values as of October 31, 2006 of the secured convertible debenture. There was no comparable charge in Fiscal 2008 Quarter as the warrant and embedded derivative liability was settled in October 2007.
 
No provision for income taxes was made for either Fiscal Quarter due to significant tax losses during and prior to such periods.
 
On January 31, 2008, our cash balance was $2,826,873, and our working capital was $1,612,727, primarily the result of net proceeds of approximately $8,452,342 from the issuance of common stock in a private placement in October 2007 less the cost of retiring outstanding debt and interest of approximately $2,889,999, purchase of warrants $600,000 and the higher overall cost of development and operations as a public company.
 
We intend to use our available cash and resources during the next 6 months following January 31, 2008 to prepare our Phase II clinical trial in CIN using Lovaxin C, one of our lead product candidates in development using our Listeria System, maintain our research and development team to assist in the further development of Lovaxin B (our Listeria vaccine directed toward treatment of breast cancer), and Lovaxin P (our Listeria vaccine directed toward treatment of prostate cancer) as well as in the development of several additional Listeria based vaccines for the treatment of cancer, and to enhance our manufacturing capabilities and strategic activities.
 
Contingent obligations

On July 1, 2002 (effective date) we entered into a 20-year exclusive worldwide license, with the University of Pennsylvania (“Penn”) with respect to the innovative work of Yvonne Paterson, Ph.D., Professor of Microbiology in the area of innate immunity, or the immune response attributable to immune cells, including dendritic cells, macrophages and natural killer cells, that respond to pathogens non-specifically. This agreement has been amended from time to time and was amended and restated on February 13, 2007. The First Amendment to the Amended and Restated Patent License Agreement was entered into on March 26, 2007 to exercise its option to license an additional Listeria-Based and LLO-Based Vaccine patent/docket and have agreed to license 12 other patents/dockets.

This license, unless sooner terminated in accordance with its terms, terminates upon the later of: (a) expiration of the last to expire Penn patent rights; or (b) twenty years after the effective date. The license provides us with the exclusive commercial rights to the patent portfolio developed at Penn as of the effective date, in connection with Dr. Paterson and requires us to raise capital, pay various milestone, legal, filing and licensing payments to commercialize the technology. In exchange for the license, Penn received shares of our common stock which currently represents approximately 5.9% of our common stock outstanding on a fully-diluted basis. In addition, Penn is entitled to receive a non-refundable initial license fee, license fees, royalty payments and milestone payments based on net sales and percentages of sublicense fees and certain commercial milestones, as follows: 1.5% royalties on net sales in all countries; notwithstanding this royalty rate, we have agreed to pay Penn a total of $525,000 over a three-year period as an advance minimum royalty after the first commercial sale of a product under each license (which payments we do not expect to begin within the next five years); an annual maintenance fee starting on December 31, 2008, until the first commercial sale of a Penn licensed product; a total of $157,134 in license payments in addition to the $215,700 previously paid, or a total of $372,834.

Furthermore, upon the achievement of the first sale of a product in certain fields, Penn shall be entitled to milestone payments, as follows: $2,500,000 shall be due for first commercial sale of the first product in the cancer field; and $1,000,000 shall be due upon the date of first commercial sale of a product in each of the secondary strategic fields sold. Therefore, the total potential amount of milestone payments is $3,500,000 in the cancer field.

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As a result of our payment obligations under the license assuming we have net sales in the aggregate amount of $100 million from our cancer products, our total payments to Penn over the next ten years could reach an aggregate of $5,420,000. If over the next 10 years our net sales total an aggregate amount of only $10 million from our cancer products, total payments to Penn could aggregate $4,445,000.
 
This license also grants us exclusive negotiation rights and exclusive options until June 17, 2009 to obtain exclusive licenses to new inventions on therapeutic vaccines developed by Drs. Paterson and Fred Frankel and their laboratory. Each option is granted to us at no cost and provides a six-month exercise period from the date of disclosure. Under this option we have finalized the First Amendment to the Amended and Restated Agreement for one docket and have negotiated licenses for more 12 dockets, with each docket having the potential of more than one patent. These dockets represent a majority of our pending patents and although we have agreed to a fee of $311,000 we are negotiating in good faith the term of the form of payment and have not finalized the Second Amendment.

Item 3. Controls and Procedures.
 
As of the end of the period covered by this report, based on an evaluation of the Company’s disclosure controls and procedures (as defined in Rules 13a-15(e) under the Securities Exchange Act of 1934), each of the Chief Executive Officer and the Vice President of Finance, Principal Financial Officer of the Company, has concluded that the Company’s disclosure controls and procedures are effective to ensure that information required to be disclosed by the Company in its Exchange Act reports is recorded, processed, summarized and reported within the applicable time periods specified by the rules and forms of the Securities and Exchange Commission.
 
There were no significant changes in the Company’s internal controls or in any other factors that could significantly affect those controls subsequent to the date of the most recent evaluation of the Company’s internal controls by the Company, including any corrective actions with regard to any significant deficiencies or material weaknesses.
 
PART II - OTHER INFORMATION
 
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

On February 1, 2008 we issued 211,853 shares of common stock in connection with liquidated damages of $31,778 incurred due to the delay in effectiveness of the registration statement on Form SB-2.
 
The above sales were exempt from registration under the Act by virtue of the provisions of Section 4(2) thereof.
 
Item 6. Exhibits and Reports on Form 8-K
 
 
31.1
Certification of Chief Executive Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002
 
31.2
Certification of Principal Financial Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002
 
32.1
Certification of Chief Executive Officer pursuant to section 906 of the Sarbanes-Oxley Act of 2002
 
32.2
Certification of Principal Financial Officer pursuant to section 906 of the Sarbanes-Oxley Act of 2002

No Reports on Form 8-K were filed during the three months ended January 31, 2008 except as follows:
 
 
i.
Report on Form 8-K filed November 27, 2007 relating to items:4.01 and 9.01.
 
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SIGNATURES


In accordance with the requirements of the Securities Exchange Act of 1934, the registrant caused this report to be signed on its behalf by the undersigned, hereunto duly authorized.
 
     
 
ADVAXIS, INC.
Registrant
 
 		  
 		  
 
Date: March 17, 2008
 By:   /s/ Thomas Moore
 
Thomas Moore
Chief Executive Officer and Chairman of the Board
   
     
 
 		  
 		  
 
  By:   /s/ Fredrick Cobb
 
Fredrick Cobb
Vice President Finance, Principal Financial Officer
   
 
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