*
|
The
remainder of this cover page shall be filled out for a reporting person’s
initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter the disclosures provided in a prior cover
page.
|
|
The
information required in the remainder of this cover page shall not be
deemed to be “filed” for the purpose of Section 18 of the Securities
Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).
|
CUSIP
No. 268158102
|
13G
|
Page 2 of 17
Pages
|
1.
|
NAMES
OF REPORTING PERSONS
Vivo
Ventures VI, LLC
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)
o
(b)
x
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER -
0 -
|
|
6.
|
SHARED
VOTING POWER
6,269,235
|
||
7.
|
SOLE
DISPOSITIVE POWER - 0 -
|
||
8.
|
SHARED
DISPOSITIVE POWER 6,269,235
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
6,269,235
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
7.1%
|
||
12.
|
TYPE
OF REPORTING PERSON
OO
|
CUSIP
No. 268158102
|
13G
|
Page 3
of 17 Pages
|
1.
|
NAMES
OF REPORTING PERSONS
Vivo
Ventures Fund VI, L.P.
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)
o
(b)
x
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER -
0 -
|
|
6.
|
SHARED
VOTING POWER
6,223,641
|
||
7.
|
SOLE
DISPOSITIVE POWER - 0 -
|
||
8.
|
SHARED
DISPOSITIVE POWER 6,223,641
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
6,223,641
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
7.0%
|
||
12.
|
TYPE
OF REPORTING PERSON
PN
|
CUSIP
No. 268158102
|
13G
|
Page 4 of 17
Pages
|
1.
|
NAMES
OF REPORTING PERSONS
Vivo
Ventures VI Affiliates Fund, L.P.
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)
o
(b)
x
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER -
0 -
|
|
6.
|
SHARED
VOTING POWER
45,594
|
||
7.
|
SOLE
DISPOSITIVE POWER - 0 -
|
||
8.
|
SHARED
DISPOSITIVE POWER 45,594
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
45,594
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
0.1%
|
||
12.
|
TYPE
OF REPORTING PERSON
PN
|
CUSIP
No. 268158102
|
13G
|
Page 5 of 17
Pages
|
1.
|
NAMES
OF REPORTING PERSONS
Vivo
Ventures V, LLC
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(b)
x
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER
OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
|
5.
|
SOLE
VOTING POWER - 0 -
|
|
6.
|
SHARED
VOTING POWER
1,476,765
|
||
7.
|
SOLE
DISPOSITIVE POWER - 0 -
|
||
8.
|
SHARED
DISPOSITIVE POWER 1,476,765
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,476,765
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.7%
|
||
12.
|
TYPE
OF REPORTING PERSON
OO
|
CUSIP
No. 268158102
|
13G
|
Page 6 of 17
Pages
|
1.
|
NAMES
OF REPORTING PERSONS
Vivo
Ventures Fund V, L.P.
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)
o
(b)
x
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER - 0 -
|
|
6.
|
SHARED
VOTING POWER
1,459,635
|
||
7.
|
SOLE
DISPOSITIVE POWER - 0 -
|
||
8.
|
SHARED
DISPOSITIVE POWER 1,459,635
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,459,635
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
1.7%
|
||
12.
|
TYPE
OF REPORTING PERSON
PN
|
CUSIP
No. 268158102
|
13G
|
Page 7 of 17
Pages
|
1.
|
NAMES
OF REPORTING PERSONS
Vivo
Ventures V Affiliates Fund, L.P.
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)
o
(b)
x
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER - 0 -
|
|
6.
|
SHARED
VOTING POWER
17,130
|
||
7.
|
SOLE
DISPOSITIVE POWER - 0 -
|
||
8.
|
SHARED
DISPOSITIVE POWER 17,130
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
17,130
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9
<0.1%
|
||
12.
|
TYPE
OF REPORTING PERSON
PN
|
CUSIP
No. 268158102
|
13G
|
Page 8 of 17
Pages
|
Item
1(a).
|
Name
of Issuer:
|
Item
1(b).
|
Address
of Issuer’s Principal Executive
Offices:
|
Item
2(a).
|
Name
of Persons Filing:
|
Item
2(b).
|
Address
of Principal Business Office or, if None,
Residence:
|
CUSIP
No. 268158102
|
13G
|
Page 9 of 17
Pages
|
Item
2(c).
|
Citizenship:
|
Item
2(d).
|
Title
of Class of Securities:
|
Item
2(e).
|
CUSIP
Number:
|
(a)
|
o
|
Broker
or dealer registered under Section 15 of the Act;
|
|
(b)
|
o
|
Bank
as defined in Section 3(a)(6) of the Act;
|
|
(c)
|
o
|
Insurance
company as defined in Section 3(a)(19) of the Act;
|
|
(d)
|
o
|
Investment
company registered under Section 8 of the Investment Company Act of
1940;
|
|
(e)
|
o
|
An
investment adviser in accordance with
§240.13d-1(b)(1)(ii)(E);
|
|
(f)
|
o
|
An
employee benefit plan or endowment fund in accordance with
§240.13d-1(b)(1)(ii)(F);
|
|
(g)
|
o
|
A
parent holding company or control person in accordance with §240.13d-1
(b)(1)(ii)(G);
|
|
(h)
|
o
|
A
savings association as defined in Section 3(b) of the Federal Deposit
Insurance Act;
|
|
(i)
|
o
|
A
church plan that is excluded from the definition of an investment company
under section 3(c)(14) of the Investment Company Act;
|
|
(j)
|
o
|
A
non-U.S. institution in accordance with
§240.13d-1(b)(1)(ii)(J);
|
|
(k)
|
o
|
Group,
in accordance with
§240.13d-1(b)(1)(ii)(K).
|
CUSIP
No. 268158102
|
13G
|
Page 10 of 17
Pages
|
Item
4.
|
Ownership.
|
Reporting Person
|
Percent
|
Vivo
Ventures VI, LLC
|
7.1%
|
Vivo
Ventures Fund VI, L.P.
|
7.0%
|
Vivo
Ventures VI Affiliates Fund, L.P.
|
0.1%
|
Vivo
Ventures V, LLC
|
1.7%
|
Vivo
Ventures Fund V, L.P.
|
1.7%
|
Vivo
Ventures V Affiliates Fund, L.P.
|
<0.1%
|
CUSIP
No. 268158102
|
13G
|
Page 11 of 17
Pages
|
Reporting Person
|
Shares
|
Vivo
Ventures VI, LLC
|
6,269,235
|
Vivo
Ventures Fund VI, L.P.
|
6,223,641
|
Vivo
Ventures VI Affiliates Fund, L.P.
|
45,594
|
Vivo
Ventures V, LLC
|
1,476,765
|
Vivo
Ventures Fund V, L.P.
|
1,459,635
|
Vivo
Ventures V Affiliates Fund, L.P.
|
17,130
|
Reporting Person
|
Shares
|
Vivo
Ventures VI, LLC
|
6,269,235
|
Vivo
Ventures Fund VI, L.P.
|
6,223,641
|
Vivo
Ventures VI Affiliates Fund, L.P.
|
45,594
|
Vivo
Ventures V, LLC
|
1,476,765
|
Vivo
Ventures Fund V, L.P.
|
1,459,635
|
Vivo
Ventures V Affiliates Fund, L.P.
|
17,130
|
Item
5.
|
Ownership
of Five Percent or Less of a Class.
|
CUSIP
No. 268158102
|
13G
|
Page 12 of 17
Pages
|
Item
6.
|
Ownership
of More than Five Percent on Behalf of Another
Person.
|
Item
7.
|
Identification
and Classification of the Subsidiary Which Acquired the Security Being
Reported on by the Parent Holding Company or Control
Person.
|
Item
8.
|
Identification
and Classification of Members of the
Group.
|
Item
9.
|
Notice
of Dissolution of Group.
|
Item
10.
|
Certification.
|
CUSIP
No. 268158102
|
13G
|
Page 13 of 17
Pages
|
VIVO
VENTURES VI, LLC
By: /s/ Frank
Kung
Name:
Frank Kung
Title:
Managing Member
VIVO
VENTURES FUND VI, L.P.
By:
Vivo Ventures VI, LLC, its general partner
By: /s/ Frank
Kung
Name:
Frank Kung
Title:
Managing Member
VIVO
VENTURES VI AFFILIATES FUND, L.P.
By:
Vivo Ventures VI, LLC, its general partner
By: /s/ Frank
Kung
Name:
Frank Kung
Title:
Managing Member
VIVO
VENTURES V, LLC
By: /s/ Frank
Kung
Name: Frank
Kung
Title: Managing
Member
VIVO
VENTURES FUND V, L.P.
By:
Vivo Ventures V, LLC, its general partner
By: /s/ Frank
Kung
Name: Frank
Kung
Title: Managing
Member
|
CUSIP
No. 268158102
|
13G
|
Page 14 of 17
Pages
|
VIVO
VENTURES V AFFILIATES FUND, L.P.
By:
Vivo Ventures V, LLC, its general partner
By: /s/ Frank
Kung
Name: Frank
Kung
Title: Managing
Member
|
CUSIP
No. 268158102
|
13G
|
Page 15 of 17
Pages
|
Exhibit Number
|
Exhibit Description
|
99.1
|
Joint
Filing Agreement
|
VIVO
VENTURES VI, LLC
By: /s/ Frank
Kung
Name:
Frank Kung
Title:
Managing Member
VIVO
VENTURES FUND VI, L.P.
By:
Vivo Ventures VI, LLC, its general partner
By: /s/ Frank
Kung
Name:
Frank Kung
Title:
Managing Member
VIVO
VENTURES VI AFFILIATES FUND, L.P.
By:
Vivo Ventures VI, LLC, its general partner
By: /s/ Frank
Kung
Name:
Frank Kung
Title:
Managing Member
|
VIVO
VENTURES V, LLC
By: /s/ Frank
Kung
Name: Frank
Kung
Title: Managing
Member
VIVO
VENTURES FUND V, L.P.
By:
Vivo Ventures V, LLC, its general partner
By: /s/ Frank
Kung
Name: Frank
Kung
Title: Managing
Member
VIVO
VENTURES V AFFILIATES FUND, L.P.
By:
Vivo Ventures V, LLC, its general partner
By: /s/ Frank
Kung
Name: Frank
Kung
Title: Managing
Member
|