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                       Securities and Exchange Commission
                              Washington, DC 20549

                                   Form 8-K/A
                                Amendment No. 2

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE

                         SECURITIES EXCHANGE ACT OF 1934



        Date of Report (Date of earliest event reported) September 24, 2004


                            PATIENT INFOSYSTEMS, INC.
             (Exact Name of Registrant as Specified in its Charter)


            Delaware                    0-22319               16-1476509
(State or Other Jurisdiction of (Commission File Number)     (IRS Employer
         Incorporation)                                    Identification No.)


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 46 Prince Street, Rochester, New York              14607
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(Address of Principal Executive Offices)          (Zip Code)
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Registrant's telephone number, including area code:  (585) 242-7200

          (Former Name or Former Address, if Changed Since Last Report)

         Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[_]  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

[_]  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

[_]  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

[_]  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))

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Explanatory Note:

     The  Registrant  hereby amends Item 9.01 of its Current  Report on Form 8-K
filed on September 24, 2004, as amended on October 7, 2004, to include unaudited
condensed pro forma  financial  statements in accordance  with  paragraph (b) of
Item 9.01 of Form 8-K.  Except as set forth in Item 9.01 below, no other changes
are made to the  Current  Report on Form 8-K filed on  September  24,  2004,  as
amended.

ITEM 9.01  Financial Statements and Exhibits

(b)  Pro Forma Financial Information

     Patient   Infosystems,   Inc.  unaudited   condensed  pro  forma  financial
statements  of  operations  for the six months ended June 30, 2004 and unaudited
condensed pro forma  statements of  operations  for the year ended  December 31,
2003.

(c)  Exhibits

Exhibit         Description
99.01           CBCA Care Management, Inc. Financial Report for the year ended
                December 31, 2003.

99.02           CBCA Care  Management,  Inc.  Financial Report for the six
                months ended June 30, 2004.

99.03           Unaudited pro forma combined condensed financial statements.




                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                             PATIENT INFOSYSTEMS, INC.

Date:  December 6, 2004                By:    /s/Kent A. Tapper
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                                             Kent A. Tapper
                                             Sr. Vice President
                                             principal accounting officer