SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
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SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c),
AND(d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b)
(AMENDMENT NO. 2 )*
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Alnylam Pharmaceuticals, Inc.
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(Name of Issuer)
Common Stock, $0.01 par value per share
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(Title of Class of Securities)
02043Q107
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(CUSIP Number)
December 31, 2005
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(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
|_| Rule 13d-1(b)
|X| Rule 13d-1(c)
|_| Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).
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1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Abingworth Management Limited
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
England
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5 SOLE VOTING POWER
0
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NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,150,000
OWNED BY
EACH -----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH: 0
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8 SHARED DISPOSITIVE POWER
2,150,000
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,150,000 shares
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)
|_|
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
10.3%
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12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
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1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Abingworth Bioventures III A L.P.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
England
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5 SOLE VOTING POWER
0
-----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,000,000 shares
OWNED BY
EACH -----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH: 0
-----------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,000,000 shares
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,000,000 shares
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)
|_|
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.6%
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12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
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1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Abingworth Bioventures III B L.P.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
England
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5 SOLE VOTING POWER
0
-----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,000,000 shares
OWNED BY
EACH -----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH: 0
-----------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,000,000 shares
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,000,000 shares
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)
|_|
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.6%
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12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
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1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Abingworth Bioventures III C L.P.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
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5 SOLE VOTING POWER
0
-----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,000,000 shares
OWNED BY
EACH -----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH: 0
-----------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,000,000 shares
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,000,000 shares
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)
|_|
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.6%
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12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
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1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Abingworth Bioventures III Executives L.P.
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) |_|
(b) |_|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
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5 SOLE VOTING POWER
0
-----------------------------------------------------
NUMBER OF 6 SHARED VOTING POWER
SHARES
BENEFICIALLY 2,000,000 shares
OWNED BY
EACH -----------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH: 0
-----------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,000,000 shares
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,000,000 shares
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS)
|_|
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.6%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
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ITEM 1(A). NAME OF ISSUER: Alnylam Pharmaceuticals, Inc. (the "Issuer")
ITEM 1(B). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
300 Third Street, Cambridge, Massachusetts 02142
ITEM 2(A). NAME OF PERSONS FILING: Abingworth Management Limited
("Abingworth Management"), Abingworth Bioventures III A L.P.
("ABV III A"), Abingworth Bioventures III B L.P. ("ABV III B"),
Abingworth Bioventures III C L.P. ("ABV III C"), and Abingworth
Bioventures III Executives L.P. ("ABV III Executives" and
together with ABV III A, ABV III B and ABV III C, the "Funds").
The foregoing individuals are collectively referred to as the
"Reporting Persons."
ITEM 2(B). ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
The business address for Abingworth Management, ABV III A,
ABV III B, ABV III C and ABV III Executives is c/o Abingworth
Management Limited, Princess House, 38 Jermyn Street, London,
England SW1Y 6DN.
ITEM 2(C). CITIZENSHIP: Abingworth Management is a corporation organized
under the laws of England. ABV III A, ABV III B and ABV III C
are limited partnerships organized under the laws of England.
ABV III Executives is a limited partnership organized under
the laws of Delaware.
ITEM 2(D). TITLE OF CLASS OF SECURITIES: Common Stock, $0.01 par value per
share
ITEM 2(E). CUSIP NUMBER: 02043Q107
ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b) OR
13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:
Not applicable
ITEM 4. OWNERSHIP:
(a) Amount Beneficially Owned: ABV III A is the record owner of
1,004,001 shares of Common Stock (the "ABV III A Shares") as
of December 31, 2005. ABV III B is the record owner of 612,874
shares of Common Stock (the "ABV III B Shares") as of December
31, 2005. ABV III C is the record owner of 367,126 shares of
Common Stock (the "ABV III C Shares") as of December 31, 2005.
ABV III Executives is the record owner of 15,999 shares of
Common Stock ("ABV III Executives Shares" and together with
ABV III A Shares, ABV III B Shares and ABV III C Shares the
"ABV III Shares") as of December 31, 2005. Collectively, the
Funds beneficially own 2,000,000 shares of Common Stock.
The Funds share a manager, Abingworth Management, and are
affiliated funds, and, on this basis, may be deemed to
beneficially own the shares held by one another. Each of
the Funds disclaims beneficial ownership of such shares of
Common Stock except for the shares, if any, such ABV III
Fund holds of record. Abingworth Management as the manager
of ABV III A, ABV III B, ABV III C, ABV III Executives and
Abingworth Bioequities Master Fund Limited ("ABE") may be
deemed to beneficially own the ABV III Shares and the
shares held of record by ABE, representing an aggregate of
2,150,000 shares of Common Stock.
(b) Percent of Class: The Funds, collectively, beneficially own
9.6% of the outstanding Common Stock of the Issuer. Abingworth
Management may be deemed to beneficially own the ABV III
Shares and the shares of Common Stock held of record by ABE,
representing an aggregate of 10.3% of the outstanding Common
Stock of the Issuer.
The foregoing percentages are calculated based on the
20,913,576 shares of Common Stock reported to be outstanding as
of September 30, 2005 in the Issuer's Form 10-Q filed with the
Securities Exchange Commission on November 14, 2005.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: see line
5 of cover sheets.
(ii) shared power to vote or to direct the vote: see
line 6 of cover sheets.
(iii) sole power to dispose or to direct the
disposition: see line 7 of cover sheets.
(iv) shared power to dispose or to direct the
disposition: see line 8 of cover sheets.
ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
Not applicable.
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.
Not applicable.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
COMPANY.
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
Not applicable.
ITEM 9. NOTICE OF DISSOLUTION OF GROUP.
Not applicable.
ITEM 10. CERTIFICATION.
By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and
are not held for the purpose of or with the effect of changing
or influencing the control of the issuer of the securities and
were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.
SIGNATURE
After reasonable inquiry and to the best of his knowledge and belief,
the undersigned certifies that the information set forth in this statement is
true, complete and correct.
Date: February 9, 2006
ABINGWORTH MANAGEMENT LIMITED
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III A L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III B L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III C L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III EXECUTIVES L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
EXHIBIT 1
AGREEMENT
Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934,
the undersigned hereby agree that only one statement containing the information
required by Schedule 13G need be filed with respect to the ownership by each of
the undersigned of shares of Common Stock of Alnylam Pharmaceuticals, Inc.
EXECUTED as a sealed instrument this 9th day of February, 2006.
ABINGWORTH MANAGEMENT LIMITED
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III A L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III B L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III C L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director
ABINGWORTH BIOVENTURES III EXECUTIVES L.P.
By: Abingworth Management Limited, its Manager
By: /s/ James Abell
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Name: James Abell
Title: Executive Director