UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                              Washington, DC 20549

                                    FORM 8-K

                                 CURRENT REPORT


     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

         Date of Report (Date of earliest event reported): March 9, 2005

                         Callisto Pharmaceuticals, Inc.
             (Exact name of registrant as specified in its charter)


Delaware                              001-32325             13-3894575
(State or other jurisdiction          (Commission           IRS Employer
of incorporation or organization)     File Number)          Identification No.)

                        420 Lexington Avenue, Suite 1609
                            New York, New York 10170
                    (Address of principal executive offices)

Registrant's telephone number, including area code: (212) 297-0010

          (Former name or former address, if changed since last report)


         Check the  appropriate  box below if the Form 8-K filing is intended to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions:

[ ]  Written communication pursuant to Rule 425 under the Securities Act (17 CFR
     230.425)

[ ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

[ ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

[ ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))





ITEM 1.01   ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

     The information required to be disclosed in this Item 1.01 is incorporated
herein by reference from Item 3.02.

 ITEM 3.02  UNREGISTERED SALES OF EQUITY SECURITIES.


     On March 9, 2005, Callisto  Pharmaceuticals,  Inc. (the "Company") closed a
private  placement  of  1,985,791  shares of  common  stock to  certain  current
institutional investors and certain members of management (the "Investors"). The
shares were sold pursuant to a Common Stock Purchase Agreement dated as of March
8, 2005  between the Company  and the  Investors  (the  "Common  Stock  Purchase
Agreement").  The shares  were sold at a price of $1.52 per share for  aggregate
proceeds of approximately $3.02 million.

     In connection  with the offer and sale of securities to the Investors,  the
Company  relied on the exemption from  registration  provided by Section 4(2) of
the  Securities  Act of 1933, as amended (the  "Securities  Act"),  and Rule 506
promulgated thereunder.  The Company believes that the Investors are "accredited
investors",  as such  term is  defined  in Rule  501(a)  promulgated  under  the
Securities Act.

     Panetta Partners, Ltd., a limited partnership of which Gabriele M. Cerrone,
the  Company's  Chairman  of the Board is the sole  managing  partner  purchased
25,000 shares in the private  placement.  In such capacity,  he exercises voting
and  dispositive  control  over  shares  owned  by  Panetta  in  which he has no
pecuniary interest.  Panetta is also a principal  stockholder of the Company. In
addition, Gary S. Jacob, the Company's Chief Executive Officer, purchased 16,448
shares in the  private  placement  and  Christoph  Bruening,  a director  of the
Company,  purchased 20,000 shares in the private  placement.  Each did so at the
specific request of the institutional  investors.  The Company's audit committee
determined  that  the  participation  by  such  members  of  management  did not
constitute a conflict of interest  under the Company's  current Code of Business
Conduct and Ethics.

     Pursuant to the Common Stock Purchase Agreement,  the Company has agreed to
file, within 30 days after the closing,  a registration  statement  covering the
resale of the shares of common stock sold to the  Investors A copy of the Common
Stock Purchase  Agreement filed herewith as Exhibit 10.1 is incorporated  herein
by reference.

ITEM 9.01   FINANCIAL STATEMENTS AND EXHIBITS.

     (c)  Exhibits.

          10.1    Form of Common Stock  Purchase  Agreement  dated March 8, 2005
                  between  Callisto   Pharmaceuticals,  Inc. and  the  investors
                  listed on Exhibit A thereto.

          99.1    Press Release dated March 10, 2005.

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                                    SIGNATURE


         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

Dated:   March 15, 2005


                                            CALLISTO PHARMACEUTICALS, INC.



                                            By: /s/ Gary S. Jacob
                                                ---------------------
                                                Gary S. Jacob, Ph.D.
                                                Chief Executive Officer


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