UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                                Vermillion, Inc.
                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
                         (Title of Class of Securities)

                                    92407M107
                                 (CUSIP Number)

                                 August 27, 2007
             (Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).







                               Page 1 of 11 Pages





CUSIP No. 92407M107                     13G                  Page 2 of 11 Pages


--------------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Highbridge International LLC
--------------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
--------------------------------------------------------------------------------
     (3)    SEC USE ONLY
--------------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            Cayman Islands, British West Indies
--------------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         -----------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    5,476,190 shares of Common Stock
OWNED BY       -----------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      -----------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                           [ ]
--------------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                    8.59%
--------------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                    OO
--------------------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 92407M107                     13G                  Page 3 of 11 Pages


--------------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Highbridge Capital Management, LLC              20-1901985
--------------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
--------------------------------------------------------------------------------
     (3)    SEC USE ONLY
--------------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            State of Delaware
--------------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         -----------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    5,476,190 shares of Common Stock
OWNED BY       -----------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      -----------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                         [ ]
--------------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                    8.59%
--------------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                    OO
--------------------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 92407M107                     13G                  Page 4 of 11 Pages


--------------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Glenn Dubin
--------------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
--------------------------------------------------------------------------------
     (3)    SEC USE ONLY
--------------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
--------------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         -----------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    5,476,190 shares of Common Stock
OWNED BY       -----------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      -----------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                         [ ]
--------------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                    8.59%
--------------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                    IN
--------------------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 92407M107                     13G                  Page 5 of 11 Pages


--------------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS

            Henry Swieca
--------------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                               (a)  [X]
                                                               (b)  [ ]
--------------------------------------------------------------------------------
     (3)    SEC USE ONLY
--------------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
--------------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         -----------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    5,476,190 shares of Common Stock
OWNED BY       -----------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      -----------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                    5,476,190 shares of Common Stock
--------------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **
                                                                           [ ]
--------------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                    8.59%
--------------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                    IN
--------------------------------------------------------------------------------

                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 92407M107                     13G                  Page 6 of 11 Pages


This statement on Schedule 13G (this "Statement") relates to the 5,476,190
shares (the "Owned Shares") of common stock, par value $0.001 per share (the
"Common Stock"), of Vermillion, Inc., a Delaware corporation (the "Company"),
held by Highbridge International LLC. In addition to the Owned Shares, the
Reporting Persons (as defined below) may be deemed to beneficially own (i)
4,380,952 shares of Common Stock issuable to Highbridge International LLC upon
the exercise of warrants to purchase shares of Common Stock and (ii) 5,550,000
shares of Common Stock issuable to Highbridge International LLC upon the
conversion of $11,100,000 principal amount of 7.00% Convertible Senior Notes due
2011. However, pursuant to the terms of the relevant instruments, Highbridge
International LLC cannot exercise or convert any of these warrants or
convertible notes until such time as Highbridge International LLC would not
beneficially own after any such exercise or conversion more than 4.99% of the
outstanding Common Stock.

Item 1.

(a)  Name of Issuer

          Vermillion, Inc. (the "Company")

(b)  Address of Issuer's Principal Executive Offices

          6611 Dumbarton Circle
          Fremont, California 94555


Item 2(a).  Name of Person Filing
Item 2(b).  Address of Principal Business Office
Item 2(c).  Citizenship


          HIGHBRIDGE INTERNATIONAL LLC
          c/o Harmonic Fund Services
          The Cayman Corporate Centre, 4th Floor
          27 Hospital Road
          Grand Cayman, Cayman Islands, British West Indies
          Citizenship:  Cayman Islands, British West Indies

          HIGHBRIDGE CAPITAL MANAGEMENT, LLC IRS #: 20-1901985
          9 West 57th Street, 27th Floor
          New York, New York  10019
          Citizenship:  State of Delaware

          GLENN DUBIN
          c/o Highbridge Capital Management, LLC
          9 West 57th Street, 27th Floor
          New York, New York 10019
          Citizenship:  United States

          HENRY SWIECA
          c/o Highbridge Capital Management, LLC
          9 West 57th Street, 27th Floor
          New York, New York 10019
          Citizenship:  United States






CUSIP No. 92407M107                     13G                  Page 7 of 11 Pages


Item 2(d)     Title of Class of Securities

          Common Stock, $0.001 par value

Item 2(e)     CUSIP Number

          92407M107

Item 3. If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or
(c), check whether the person filing is a:

(a) [ ]   Broker or dealer registered under Section 15 of the Act
          (15 U.S.C. 78o).

(b) [ ]   Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).

(c) [ ]   Insurance company as defined in Section 3(a)(19) of the Act
          (15 U.S.C. 78c).

(d) [ ]   Investment company registered under Section 8 of the Investment
          Company Act of 1940 (15 U.S.C. 80a-8).

(e) [ ]   An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

(f) [ ]   An employee benefit plan or endowment fund in accordance with
          Rule 13d-1(b)(1)(ii)(F);

(g) [ ]   A parent holding company or control person in accordance with
          Rule 13d-1(b)(1)(ii)(G);

(h) [ ]   A savings association as defined in Section 3(b) of the Federal
          Deposit Insurance Act (12 U.S.C. 1813);

(i) [ ]   A church plan that is excluded from the definition of an investment
          company under Section 3(c)(14) of the Investment Company Act of 1940
          (15 U.S.C. 80a-3);

(j) [ ]   Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box. [X]

Item 4.       Ownership

          Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

          (a)  Amount beneficially owned:

          As of the date of this filing, each of the Reporting Persons may be
deemed the beneficial owner of 5,476,190 shares of Common Stock held by
Highbridge International LLC.

          Highbridge Capital Management, LLC is the trading manager of
Highbridge International LLC. Glenn Dubin is a Co-Chief Executive Officer of
Highbridge Capital Management, LLC. Henry Swieca is a Co-Chief Executive Officer
of Highbridge Capital Management, LLC. The foregoing should not be construed in
and of itself as an admission by any Reporting Person as to beneficial ownership
of Common Stock owned by another Reporting Person. In addition, each of






CUSIP No. 92407M107                     13G                  Page 8 of 11 Pages


Highbridge Capital Management, LLC, Glenn Dubin and Henry Swieca disclaims
beneficial ownership of Common Stock owned by Highbridge International LLC.


          (b)  Percent of class:

          The Company's Quarterly Report on Form 10-Q that was filed on August
13, 2007, indicates there were 39,263,842 shares of Common Stock outstanding as
of July 31, 2007. In addition, the Company issued 24,500,000 shares of Common
Stock on August 29, 2007, as disclosed in the Current Report on Form 8-K filed
on August 29, 2007. Therefore, as of August 29, 2007, the total number of
outstanding shares of the Company is 63,763,842. Based on the Company's
outstanding shares of Common Stock, each of Highbridge International LLC,
Highbridge Capital Management LLC, Glenn Dubin and Henry Swieca may be deemed to
beneficially own 8.59% of the outstanding shares of Common Stock of the Company.
The foregoing should not be construed in and of itself as an admission by any
Reporting Person as to beneficial ownership of shares of Common Stock owned by
another Reporting Person.

          (c)  Number of shares as to which such person has:

               (i)  Sole power to vote or to direct the vote

                    0

              (ii)  Shared power to vote or to direct the vote

                    See Item 4(a)

             (iii)  Sole power to dispose or to direct the disposition of

                    0

              (iv)  Shared power to dispose or to direct the disposition of

                    See Item 4(a)

Item 5.   Ownership of Five Percent or Less of a Class

     Not applicable.

Item 6.   Ownership of More than Five Percent on Behalf of Another Person

     Not applicable.

Item  7.  Identification and Classification of the Subsidiary Which Acquired
          the Security Being Reported on by the Parent Holding Company or
          Control Person

     Not applicable.

Item 8.   Identification and Classification of Members of the Group

     See Exhibit I.

Item 9.   Notice of Dissolution of Group

     Not applicable.






CUSIP No. 92407M107                     13G                  Page 9 of 11 Pages


Item 10. Certification

          By signing below each of the undersigned certifies that, to the best
of its knowledge and belief, the securities referred to above were not acquired
and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.

Exhibits:

Exhibit I: Joint Filing Agreement, dated as of September 5, 2007, by and among
Highbridge International LLC, Highbridge Capital Management, LLC, Glenn Dubin
and Henry Swieca.







CUSIP No. 92407M107                     13G                  Page 10 of 11 Pages


SIGNATURES

          After reasonable inquiry and to the best of its knowledge and belief,
each of the undersigned certifies that the information with respect to it set
forth in this statement is true, complete, and correct.

Dated: September 5, 2007



HIGHBRIDGE INTERNATIONAL LLC             HIGHBRIDGE CAPITAL MANAGEMENT, LLC

By: Highbridge Capital Management, LLC
    its Trading Manager


By: /s/ Carolyn Rubin                    By: /s/ Carolyn Rubin
    ---------------------------------        -----------------------------------
Name:  Carolyn Rubin                     Name:  Carolyn Rubin
Title: Managing Director                 Title: Managing Director


/s/ Glenn Dubin                          /s/ Henry Swieca
-------------------------------------    ---------------------------------------
GLENN DUBIN                              HENRY SWIECA







CUSIP No. 92407M107                     13G                  Page 11 of 11 Pages


                                    EXHIBIT I

                             JOINT FILING AGREEMENT

This will confirm the agreement by and among the undersigned that the Schedule
13G filed with the Securities and Exchange Commission on or about the date
hereof with respect to the beneficial ownership by the undersigned of the Common
Stock, $0.001 par value, of Vermillion, Inc., is being filed, and all amendments
thereto will be filed, on behalf of each of the persons and entities named below
in accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as
amended. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

Dated as of September 5, 2007



HIGHBRIDGE INTERNATIONAL LLC             HIGHBRIDGE CAPITAL MANAGEMENT, LLC

By: Highbridge Capital Management, LLC
    its Trading Manager


By: /s/ Carolyn Rubin                    By: /s/ Carolyn Rubin
    ---------------------------------        -----------------------------------
Name:  Carolyn Rubin                     Name:  Carolyn Rubin
Title: Managing Director                 Title: Managing Director


/s/ Glenn Dubin                          /s/ Henry Swieca
------------------------------------     ---------------------------------------
GLENN DUBIN                              HENRY SWIECA