UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K
                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): October 4, 2006

                          IR BIOSCIENCES HOLDINGS, INC.
                 (Exact name of registrant specified in charter)


      Delaware                       033-05384                 13-3301899
----------------------         ----------------------    ---------------------
      (State of                  (Commission File           (IRS Employer
    Incorporation)                   Number)              Identification No.)

                         4021 N. 75th Street, Suite 201
                              Scottsdale, AZ 85251
               (Address of principal executive offices) (Zip Code)

                                 (480) 922-3926
              (Registrant's telephone number, including area code)

                                       N/A
          (Former name or former address, if changed since last report

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_|  Written  communications  pursuant to Rule 425 under the  Securities Act (17
     CFR 230.425)

|_|  Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a-12)

|_|  Pre-commencement   communications  pursuant  to  Rule  14d-2(b)  under  the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement   communications  pursuant  to  Rule  13e-4(c)  under  the
     Exchange Act (17 CFR 240.13e-4(c))











ITEM 1.01. ENTRY INTO A MATERIAL DEFINITIVE AGREEMENT.

The information in Item 3.02, below, is incorporated herein by reference.

ITEM 3.02 UNREGISTERED SALES OF EQUITY SECURITIES.

On October 4, 2006, IR Biosciences  Holdings,  Inc. (the "Company")  effected an
initial closing of a private placement, whereby the Company sold an aggregate of
$2,276,500  worth of units ("Units") to accredited  investors as defined by Rule
501 under the Securities Act of 1933, as amended (the transaction is referred to
herein as the "Private Placement").

Pursuant  to the  terms of the  subscription  agreement,  each Unit was sold for
$25,000 and consisted of (i) 156,250 shares of common stock of the Company,  par
value $0.001 per share (the "Common Stock"); and (ii) a warrant to purchase,  at
any time  prior to the fifth  anniversary  following  the final  closing  of the
Private  Placement,  78,125 shares of Common Stock at an exercise price of $0.50
per share.  A total of  14,228,125  shares and  7,114,063  warrants were sold to
investors at the initial closing of the Private Placement. The Company agreed to
file a  registration  statement,  covering  the  securities  sold in the Private
Placement,  not before 180 days after the final closing of the Private Placement
and not later than 190 days after the final  closing of the  Private  Placement.
The shares and warrants  were  offered and sold to  investors  in reliance  upon
exemptions from  registration  pursuant to Section 4(2) under the Securities Act
of 1933,  as amended,  and Rule 506  promulgated  thereunder.  In addition,  the
Company may elect to redeem the warrants  (but not less than all the  warrants),
upon certain conditions and after providing at least thirty-days  written notice
to warrant holders.

In  connection  with the Private  Placement,  the Company  issued an  additional
2,276,500  shares of Common Stock to the placement agent or its designees,  upon
the  initial  closing  of the  Private  Placement.  The  shares  were  issued as
consideration  for the placement agent's services in connection with the Private
Placement.  The shares were issued in reliance upon exemptions from registration
pursuant to Section 4(2) under the Securities Act of 1933, as amended,  and Rule
506 promulgated  thereunder.  In addition, the placement agent received $349,776
in commission and expenses as compensation for its services.

THIS CURRENT REPORT IS NOT AN OFFER OF SECURITIES FOR SALE. ANY SECURITIES  SOLD
IN THE PRIVATE  PLACEMENT WILL NOT HAVE BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED,  AND MAY NOT BE OFFERED OR SOLD IN THE UNITED STATES UNLESS
REGISTERED  UNDER THE  SECURITIES  ACT OF 1933,  AS  AMENDED,  OR PURSUANT TO AN
EXEMPTION FROM SUCH REGISTRATION.





                                    SIGNATURE

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.



                                      IR BIOSCIENCES HOLDINGS, INC.

Date: October 10, 2006                By: /s/ Michael Wilhelm
                                          -----------------------
                                          Michael Wilhelm
                                          President
                                          (Duly Authorized Officer)