UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                  -------------

                                    FORM 8-K

                                 CURRENT REPORT
                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

  Date of Report (Date of earliest event reported): June 2, 2006 (June 8, 2006)

                                  -------------

                            LIFEPOINT HOSPITALS, INC.
             (Exact name of registrant as specified in its charter)


          Delaware                       0-51251                 20-1538254
(State or Other Jurisdiction           (Commission              (IRS Employer
     of Incorporation)                 File Number)          Identification No.)


           103 Powell Court, Suite 200
               Brentwood, Tennessee                               37027
     (Address of principal executive offices)                   (Zip Code)

                                 (615) 372-8500
              (Registrant's telephone number, including area code)

                                 Not applicable
          (Former Name or Former Address, if Changed Since Last Report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

o Written communication pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))


                         Exhibit Index located on Page 4




                                Page 1 of 4 pages



Item 1.01. Entry into a Material Definitive Agreement.

       On June 2, 2006, LifePoint  Hospitals,  Inc., a Delaware corporation (the
"Company"),  entered  into an  agreement  with HCA  (NYSE:  HCA) to amend  their
previously  announced  agreement.  Under  the terms of the  modified  agreement,
LifePoint will acquire three  hospitals in West Virginia and one in Virginia for
a purchase  price of $239  million  plus  specific  working  capital,  including
inventory and the  assumption of paid time off, as defined in the new agreement.
The  transaction  is subject to certain  closing  conditions  and is expected to
close by June 30, 2006.  The four  facilities to be acquired are 200-bed  Clinch
Valley Medical  Center,  Richlands,  Virginia;  325-bed St.  Joseph's  Hospital,
Parkersburg,  West Virginia;  155-bed Saint Francis Hospital,  Charleston,  West
Virginia;  and 369-bed Raleigh General  Hospital,  Beckley,  West Virginia.  The
modified  agreement provides that HCA will indemnify the Company with respect to
certain  specified  items.  Additionally,  HCA has agreed to repurchase the West
Virginia  facilities  in the event of a revocation of the  certificates  of need
granted  by the West  Virginia  Healthcare  Authority.  Simultaneously  with the
closing of the transaction,  the Company will classify St. Joseph's Hospital and
Saint Francis Hospital as assets held for sale. The modified  agreement excludes
68-bed Putnam General Hospital, Hurricane, West Virginia, which will continue to
be owned by HCA. A copy of the press release  announcing the modified  agreement
is attached hereto as Exhibit 99 and is incorporated by reference herein.

       The Company  was formed as a division of HCA in November  1997 to operate
general acute care hospitals in non-urban communities and became an independent,
publicly  traded company on May 11, 1999 when HCA  distributed  all  outstanding
shares  of the  Company's  common  stock  to its  stockholders.  As part of this
transaction,  the Company entered into agreements with HCA to define the ongoing
relationships  following the distribution and to allocate tax, employee benefits
and other  liabilities  and  obligations  arising from periods  prior to May 11,
1999. The Company continues to rely on HCA-Information  Technology and Services,
Inc. ("HCA-IT"),  an HCA affiliate,  for information  systems.  Under a contract
with a term that will expire on December 31, 2009,  HCA-IT  provides the Company
with  various  information  systems  services,  including,  but not  limited to,
financial,  clinical, patient accounting and network information services. Refer
to the  Company's  2005 Annual Report on Form 10-K for more  information  on the
relationship between the Company and HCA.



Item 9.01. Financial Statements and Exhibits.

       (c)    Exhibits

              99 Press Release of LifePoint Hospitals, Inc., dated June 5, 2006.













                                Page 2 of 4 pages



                                   SIGNATURES

       Pursuant to the requirements of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

Date: June 8, 2006                      LIFEPOINT HOSPITALS, INC.

                                        By:  /s/ William F. Carpenter III
                                             -----------------------------------

                                             William F. Carpenter III
                                             Executive Vice President, General
                                             Counsel and Secretary








                                Page 3 of 4 pages



                                  EXHIBIT INDEX

Exhibit
Number           Description
-------         ----------------------------------------------------------------

99               Press Release of LifePoint Hospitals, Inc., dated June 5, 2006.


























                                Page 4 of 4 pages