Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Shorter Simon C.
2. Date of Event Requiring Statement (Month/Day/Year)
11/01/2007
3. Issuer Name and Ticker or Trading Symbol
VERMILLION, INC. [VRML]
(Last)
(First)
(Middle)
C/O VERMILLION, INC., 47350 FREMONT BLVD.
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP, Corp Business Development
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

FREMONT, CA 94538
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 7,500 (1)
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy)   (2) 09/19/2014 Common Stock 75,000 (8) $ 3.68 (9) D  
Stock Option (Right to Buy)   (3) 04/05/2015 Common Stock 15,000 (8) $ 1.8 (9) D  
Stock Option (Right to Buy)   (4) 08/04/2015 Common Stock 15,000 (8) $ 2.19 (9) D  
Stock Option (Right to Buy)   (5) 12/19/2015 Common Stock 10,000 (8) $ 0.9 (9) D  
Stock Option (Right to Buy)   (6) 06/06/2016 Common Stock 75,000 (8) $ 1.2 (9) D  
Stock Option (Right to Buy)   (7) 04/25/2017 Common Stock 44,990 (8) $ 1.47 (9) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Shorter Simon C.
C/O VERMILLION, INC.
47350 FREMONT BLVD.
FREMONT, CA 94538
      VP, Corp Business Development  

Signatures

/s/ S. C. Shorter 08/22/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The number of shares of Common Stock reported in Column 2 does not reflect a 1-for-10 reverse stock split, which became effective at the close of business on March 3, 2008, pursuant to which each share of Common Stock was converted into 1/10 of a share of Common Stock.
(2) This option vests in 60 consecutive equal monthly installments, beginning on October 20, 2004.
(3) This option vests in 60 consecutive equal monthly installments, beginning on May 6, 2005.
(4) This option vests in 24 consecutive equal monthly installments, beginning on September 5, 2005.
(5) This option vests in 24 consecutive equal monthly installments, beginning on January 20, 2006.
(6) This option vests in 48 consecutive equal monthly installments, beginning on July 7, 2006.
(7) This option vests in 48 consecutive equal monthly installments, beginning on May 26, 2007.
(8) The number of underlying shares of Common Stock identified in Column 3 does not reflect a 1-for-10 reverse stock split, which became effective at the close of business on March 3, 2008, pursuant to which each share of Common Stock was converted into 1/10 of a share of Common Stock.
(9) The exercise price of derivative securities identified in Column 4 does not reflect a 1-for-10 reverse stock split, which became effective at the close of business on March 3, 2008, pursuant to which the exercise price of derivative securities increased by a factor of 10.

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